@article {144,
	title = {Pyrethrins combined with piperonyl butoxide (RID) vs 1\% permethrin (NIX) in the treatment of head lice},
	journal = {American Journal of Diseases of Children},
	volume = {142},
	year = {1988},
	note = {LR: 20041117; JID: 0370471; 0 (Drug Combinations); 0 (Pyrethrins); 0 (RID); 51-03-6 (Piperonyl Butoxide); 52645-53-1 (Permethrin); ppublish},
	month = {1988},
	pages = {768 - 769},
	abstract = {In a randomized controlled trial, 58 subjects were treated for Pediculus humanus var capitis with either pyrethrins combined with piperonyl butoxide (RID, Pfizer Inc, New York) or 1\% permethrin (NIX, Burroughs Wellcome Co, Research Triangle Park, NC); 31 subjects received RID and 27 subjects received NIX. Both products were applied according to manufacturer{\textquoteright}s directions so that NIX was applied only on the first visit and RID was applied on the first visit and again seven days later. After each treatment with a pediculicide, the comb supplied by the manufacturer was used to remove nits. Seven days after the initial visit, NIX was determined to be significantly better than RID for eradicating the lice infestation. Of the 27 subjects receiving NIX, 26 were live free vs 14 of the 31 RID-treated subjects. At day 14, there was no statistically significant difference in the treatments (27 of 27 NIX-treated vs 29 of 31 RID-treated subjects were lice free). The RID comb was superior to the NIX comb for nit removal. Both treatments were effective and well tolerated, and no subject experienced adverse reactions.},
	keywords = {adolescent, adult, animals, child, Child, Preschool, Comparative Study, Drug Combinations/therapeutic use, Drug Evaluation, humans, Lice Infestations/drug therapy, Pediculus, Permethrin, Piperonyl Butoxide, Pyrethrum, Random Allocation, Research Support, Non-U.S. Gov{\textquoteright}t, scalp},
	url = {http://www.phthiraptera.info/Publications/45388.pdf},
	author = {Carson,D. S. and Tribble,P. W. and Weart,C. W.}
}
@article {146,
	title = {Comparison of pediculicidal and ovicidal effects of two pyrethrin-piperonyl-butoxide agents},
	journal = {Clinical therapeutics},
	volume = {9},
	year = {1987},
	note = {LR: 20041117; JID: 7706726; 0 (Drug Combinations); 0 (Pyrethrins); 51-03-6 (Piperonyl Butoxide); ppublish},
	month = {1987},
	pages = {368 - 372},
	address = {UNITED STATES},
	abstract = {A pyrethrin-piperonyl-butoxide shampoo was compared with a similarly formulated lotion for their pediculicidal and ovicidal effects against head lice. Forty children with active Pediculus humanus capitis infestation were randomly assigned to one of two groups for a single treatment with either the shampoo or the lotion. An average of ten nits were taken from each patient both before and after treatment. These eggs were incubated for 14 days, the resulting lice counted, and their conditions noted. Lice recovered from the rinse water after treatment were also counted and observed. Although both products proved to be effective in killing lice, the shampoo had greater ovicidal efficacy, 50\% versus 25\% for the lotion, after adjustment for natural mortality of the ova.},
	keywords = {Administration, Topical, child, Child, Preschool, Comparative Study, Drug Combinations, humans, Lice Infestations/drug therapy, Ovum/drug effects, Pediculus, Piperonyl Butoxide, Pyrethrum, scalp},
	isbn = {0149-2918},
	author = {Pitman,N. K. and Hernandez,A. and Hernandez,E.}
}
@article {98,
	title = {Baseline susceptibility of a laboratory strain of Pediculus humanus humanus (Anoplura: Pediculidae) using a modified World Health Organization testing protocol},
	journal = {Journal of Medical Entomology},
	volume = {36},
	year = {1999},
	month = {1999},
	pages = {903 - 905},
	abstract = {The World Health Organization (WHO) protocol for determining resistance in body lice, Pediculus humanus humanus (L.), requires holding lice for long periods, which makes successful execution of the test difficult in field settings. The purpose of this study was to modify the WHO test procedure to make the holding period of lice shorter and the handling of lice easier. Susceptible lice from a laboratory colony were placed in a petri dish containing a paper that had been treated with an insecticide solution. After 6 h, the petri dish was turned on its side and lightly tapped on the table. Lice that were unable to cling to the paper were counted as knocked down. The KD50 in mg (AI)/ml of the insecticide solution used to treat the papers was as follows: lindane 0.060, permethrin 0.115, d-phenothrin 0.554, and malathion 1.008. If the diagnostic dose is set at 2 times the KD99, for this test procedure the diagnostic doses and WHO equivalent dose would be lindane, 0.368 mg (AI)/ml (WHO 0.132\%); permethrin, 0.498 mg (AI)/ml (WHO 0.206\%); d-phenothrin, 2.680 mg (AI)/ml (WHO 1.107\%); and malathion, 5.212 mg (AI)/ml (WHO 2.020\%).},
	keywords = {animals, Animals, Laboratory, entomology, insecticide, Insecticide Resistance, lindane, malathion, Pediculus, Permethrin, Pyrethrum, World Health Organization},
	url = {http://www.phthiraptera.info/Publications/45047.pdf},
	author = {Zeichner,Brian C.}
}
@article {105,
	title = {What{\textquoteright}s eating you? Pediculus humanus (head louse and body louse)},
	journal = {Cutis},
	volume = {63},
	year = {1999},
	month = {1999},
	pages = {259 - 264},
	abstract = {Head lice remain a common problem worldwide. As resistance to available therapeutic agents can emerge rapidly, there is a need for continued research to find new and better agents. Until better agents are available, clinicians may find that rotational therapy, using different agents, may help to slow the emergence of resistance. Physical modalities, such as mechanical nit and louse removal and occlusive agents to asphyxiate the lice, should not be ignored, especially in light of our limited therapeutic armamentarium. All therapeutic agents are doomed to failure if infestation is allowed to recur. Classmates, playmates, and family members of infested children should be inspected for head lice. Efforts should be directed at fomite control and nit removal. Louse infestation must be addressed as a community-wide problem. Body lice remain important vectors of disease. War, natural disaster, and poverty favor the spread of body lice. As we work to solve these seemingly eternal problems, we must develop better agents to treat infestation and prevent the spread of body lice.},
	keywords = {adult, animals, carbaryl, child, Diagnosis, Differential, Drug Combinations, humans, insecticide, Ivermectin/therapeutic use, Lice Infestations/diagnosis/drug therapy, Lindane/therapeutic use, malathion, Pediculus, Permethrin, Piperonyl Butoxide, Pyrethrum, Research Support, Non-U.S. Gov{\textquoteright}t, Trimethoprim},
	author = {Elston,D. M.}
}
@article {110,
	title = {Treatment of Pediculus humanus var. capitis infestation in Cowlitz County, Washington, with ivermectin and the LiceMeister(R) comb},
	journal = {Pediatric Infectious Disease Journal},
	volume = {17},
	year = {1998},
	month = {1998},
	pages = {923 - 924},
	keywords = {adolescent, adult, animals, child, Child, Preschool, humans, insecticide, Insecticide Resistance, Ivermectin/therapeutic use, Lice Infestations/drug therapy, Pediculus, Permethrin, Pyrethrum, scalp dermatoses, Washington},
	author = {Bell,T. A.}
}
@article {123,
	title = {Permethrin resistance in the head louse Pediculus capitis from Israel},
	journal = {Medical and Veterinary Entomology},
	volume = {9},
	year = {1995},
	month = {1995},
	pages = {427 - 432},
	abstract = {Head lice, Pediculus capitis, were collected from children aged 3-12 years in Maale Adumin, a town near Jerusalem, after reports of control failure with the pyrethroid insecticide permethrin. A total of 1516 children were examined: living lice and eggs were found on 12.1\% of the children; or another 22.8\% of the children only nits were found. Twice as many girls as boys (8.1\% v 4\%) were infested with lice and or nits. Head lice collected from infested children were exposed to permethrin impregnated filter-papers. Log time probit mortality (Itp) regression lines were calculated for mortality data and compared to Itp lines for a similar collection of head lice made in 1989. The regression lines for the two years were significantly different, with a 4-fold decrease in susceptibility at the LT(50) level between 1989 and 1994. The slopes of the lines also suggested that the 1994 population was more heterogenous in its response to permethrin than the 1989 population. In contrast, a laboratory population of body lice (Pediculus humanus) tested with the same batch of permethrin- impregnated papers showed a slight but nonsignificant increase in susceptibility between 1989 and 1994. The results suggest that resistance to pyrethroids has developed rapidly among head lice since permethrin was introduced in 1991 as a pediculicide in Israel.},
	keywords = {body, capitis, children, control, DDT, Diptera, head, humanus, insecticide, Israel, lindane, locus, louse, mechanism, musca domestica l, pdf, pediculosis, Pediculus, Permethrin, Pyrethrum, resistance, rinse, shampoo},
	url = {http://www.phthiraptera.info/Publications/38552.pdf},
	author = {Mumcuoglu,Kosta Y. and Hemingway,Janet and Miller,Jacqueline and Ioffe-Uspensky,Inna and Klaus,Sidney and Ben-Ishai,Fiameta and Galun,Rachel}
}
@article {125,
	title = {Controlled study of malathion and d-phenothrin lotions for Pediculus humanus var capitis infested schoolchildren},
	journal = {Lancet},
	volume = {344},
	year = {1994},
	month = {1994},
	pages = {1724 - 1727},
	abstract = {Anecdotal reports have suggested that reduced efficacy of pediculicides against Pediculus humanus capitis could be related to resistance to treatments. Ovicidal and pediculicidal activities of 0.5\% malathion and 0.3\% d-phenothrin lotions were tested in an experimental model of P humanus capitis grown on rabbits to ensure that the two treatments were pharmacologically equipotent. We then did a randomised controlled trial in which the lotions were administered to 193 P humanus capitis-infested schoolchildren (malathion, 95; d-phenothrin, 98). Success rate was defined as the absence of both live lice and viable nits. Before treatment, live lice were collected and subjected to a pediculicidal test. Pharmacological tests showed 100\% killing of the rabbit-grown nits and lice after exposure to both pediculicides. On day 1 of the controlled trial, the success rate was 92\% in the malathion group (95\% CI, 0.86-0.97) and 40\% in the d-phenothrin group (0.30-0.49) (p < 0.0001); on day 7, it was 95\% in the malathion group (0.90-0.99) and 39\% in the d-phenothrin group (0.29-0.48, p < 0.0001). Malathion was also significantly more active in the pediculicidal tests compared to d-phenothrin and control. These results suggest an acquired resistance to d-phenothrin in the schoolchildren tested, since all other conditions of the administration of insecticides were standardised.},
	keywords = {animals, child, Comparative Study, humans, Insecticide Resistance, Lice Infestations/drug therapy, malathion, Pediculus, Pyrethrum, Rabbit, Research Support, Non-U.S. Gov{\textquoteright}t, scalp dermatoses},
	url = {http://www.phthiraptera.info/Publications/45219.pdf},
	author = {Chosidow,Olivier and Chastang,C. and Brue,C. and Bouvet,E. and Izri,M. and Monteny,N. and Bastuji-Garin,S. and Rousset,J. J. and Revuz,J.}
}
@article {74,
	title = {Molecular analysis of a para sodium channel gene from pyrethroid-resistant head lice, Pediculus humanus capitis (Anoplura: Pediculidae)},
	journal = {Journal of Medical Entomology},
	volume = {40},
	year = {2003},
	month = {2003},
	pages = {468 - 474},
	abstract = {The problem of pyrethroid-resistance in head lice, Pediculus humanus capitis (De Geer), is growing worldwide, and an insensitive sodium channel is suspected as the major mechanism of this resistance. We sequenced an open reading frame (ORF) encoding for the para-orthologous sodium channel from an insecticide-susceptible strain of the body louse, Pediculus humanus humanus (L.), based on conserved peptide sequences and a known partial gene sequence. Phenothrin-susceptible and -resistant head louse colonies from Japanese were individually analyzed for point mutations of the sodium channel cDNA; susceptible head and body lice differed in double homozygous synonymous substitutions. The resistant head lice shared 23 base substitutions homozygously, in which four resulted in amino acid substitutions: D11E in the N-terminal inner-membrane segment; M850T in the outer-membrane loop between segments four and five of domain II; T952I and L955 F in the trans-membrane segment five of domain II. The latter two substitutions coincided with those of pyrethroid-resistant head lice in the U.S. and U.K. (Lee et al. 2000), within the available published information on the peptide sequences. The potential mechanisms of head louse pyrethroid-resistance are discussed based on the four structural changes of the target molecule.},
	keywords = {Amino Acids, animals, Drug Resistance/genetics, humans, insecticide, Molecular Sequence Data, Pediculus, polymerase, Pyrethrum, Research Support, Non-U.S. Gov{\textquoteright}t, RNA, Messenger/genetics, sequence, Sodium Channels/chemistry/genetics},
	url = {http://www.phthiraptera.info/Publications/44754.pdf},
	author = {Tomita,Takashi and Yaguchi,Noboru and Mihara,Minoru and Takahashi,Masakazu and Agui,Noriaki and Kasai,Shinji}
}
@article {79,
	title = {Prevalence and treatment of Pediculus humanus capitis with 1\% permethrin and 0.4\% d-phenothrin in Turkey},
	journal = {Acta Medica (Hradec Kralove)},
	volume = {46},
	year = {2003},
	note = {LR: 20041117; JID: 9705947; 0 (Hair Preparations); 0 (Insecticides); 0 (Pyrethrins); 26002-80-2 (phenothrin); 52645-53-1 (Permethrin); ppublish},
	month = {2003},
	pages = {73 - 75},
	address = {Czech Republic},
	abstract = {Pediculosis humanus capitis (head lice) is an important public health problem among school children. In our study, 20,612 schoolchildren (10,367 boys, 10,245 girls) were examined for Pediculus humanus capitis in 36 elementary schools between December 1996 and February 1998 in Ankara, Turkey. The prevalence of pediculosis capitis infestation was found to be 3.4\% (701/20,612). Of these, 382 students were treated with application of 1\% permethrin cream rinse, and 184 students with 0.4\% d-phenothrin shampoo. On day 14 of the controlled trial, the success rates were 93.7\% in the 1\% permethrin cream rinse group and 75.5\% in the 0.4\% d-phenothrin shampoo group. The 1\% permethrin cream rinse was also significantly more active in pediculicidal efficacy when compared to the 0.4\% d-phenothrin shampoo (p<0.001). As a result, these findings demonstrate that pediculosis capitis still remains a widespread health problem.},
	keywords = {animals, child, Comparative Study, hair, humans, insecticide, Lice Infestations/drug therapy/epidemiology, Pediculus, Permethrin, Pyrethrum, scalp dermatoses, Single-Blind Method, Turkey/epidemiology},
	isbn = {1211-4286},
	author = {Tanyuksel,M. and Araz,R. E. and Albay,A. and Aycicek,H.}
}
@article {95,
	title = {Resistance and the control of lice on humans and production animals},
	journal = {International Journal for Parasitology},
	volume = {30},
	year = {2000},
	month = {2000},
	pages = {291 - 297},
	abstract = {Phthiraptera (lice) are specialised insects adapted to parasitise many warm-blooded vertebrates, including domestic animals and humans. Often, attempts by the host to alleviate the irritation created by lice, causes derangement of the hair/fur coat. Unless treated, this derangement may cause economic losses due to hide damage and/or downgrading of wool/hair/fur. In 1981, application of aqueous insecticide solutions (dipping) for the control of sheep body lice (Bovicola ovis) was largely superseded by off-shears pyrethroid "pour-on" treatments. By 1985, several field failures with these products were found to be due to low-level (20x) insecticide resistance. In 1990, high-level (640x) resistance was diagnosed in a New South Wales population. However, despite 30+years use, organophosphate-based products are still usually effective. Until recently, cattle lice caused little concern. Treatments were applied mainly for aesthetic reasons when cattle were to be presented for sale, and also to prevent damage to fences by rubbing cattle. However, the introduction of quality-management programmes have raised awareness of the economic losses due to hide damage associated with lice infestations. Emerging industries such as emu and alpaca farming have raised the pest status of other louse species, and necessitated insecticidal intervention. In humans, attempts to control head lice, Pediculus humanus capitis, infestations have repeatedly failed around the world.},
	keywords = {animals, Animals, Domestic, humans, insecticide, Insecticide Resistance, Lice Infestations/prevention \& control/veterinary, organophosphate, Pediculus, plants, Pyrethrum, Research Support, Non-U.S. Gov{\textquoteright}t, sheep, Sheep Diseases/prevention \& control},
	author = {Levot,G.}
}
@article {58,
	title = {Economic considerations associated with Pediculus humanus capitis infestation},
	journal = {Clinical pediatrics},
	volume = {43},
	year = {2004},
	note = {JID: 0372606; 0 (Insecticides); 0 (Pyrethrins); ppublish},
	month = {2004},
	pages = {523 - 527},
	address = {United States},
	abstract = {An estimated 6 to 12 million head lice infestations occur in the United States annually, with children ages 3 to 12 most likely to be affected. There are significant direct costs associated with treatment and indirect costs due to lost time from school. Anecdotal reports suggest that direct costs of treatment are in the hundreds of millions of dollars annually. Indirect costs are also substantial but more difficult to quantify. Examples of indirect costs include missed days from schools that use a "no nit" policy, lost wages for parents who must stay home with children, and costs of daycare for parents who cannot miss work. Contributors to the expense of treating head lice include misdiagnosis, and, consequently unneeded treatment; treatment failure due to misuse of pediculicides or other agents; and developing resistance, particularly to over-the-counter pyrethroid agents. An overview of direct and indirect costs of infestation are included in this review, along with a discussion of factors that lead to misuse and overuse of pediculicides. More accurate diagnosis of head lice infestation may provide the most effective means of controlling the costs of care and ensuring proper use of pediculicides.},
	keywords = {animals, child, Child, Preschool, Cost of Illness, Drug Costs, humans, Infant, insecticide, Lice Infestations/drug therapy/economics, Pediculus, Pyrethrum, Research Support, Non-U.S. Gov{\textquoteright}t, scalp dermatoses, U.S.A.},
	isbn = {0009-9228},
	author = {Hansen,R. C. and O{\textquoteright}Haver,J.}
}
